Meiosis Laboratory
Recombination and segregation of chromosomes and genes in meiosis is the main source of genetic diversity in populations.
The purpose of the research carried out in the laboratory of recombination and segregation analysis of the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences is to clarify the role of chromosomal rearrangements and genetic factors in the regulation of the recombination process in meiosis of animals.
About our Lab
The aim of research conducted in the laboratory is to elucidate the role of chromosomal rearrangements and genetic factors in the regulation of the recombination process in animal meiosis (meiosis group) and to develop and apply methods of recombination and segregation analysis for the identification and mapping of genes controlling diversity in complex traits in animal and human populations (genetic analysis methods group).
The meiosis group analyzes the molecular and cytogenetic mechanisms of synapsis, recombination and segregation of chromosomes in animal meiosis and the role of these processes in the evolution of populations and speciation. The laboratory has carried out a large cycle of studies to find out chromosomal polymorphism in natural populations of mammals.
New chromosomal rearrangements have been described in natural populations of different rodent species in Europe, Asia and South America.
Using modern methods of electron microscopic and immunochemical analysis, fluorescent in situ hybridization, the peculiarities of the course of meiosis, synapsis, recombination and segregation of chromosomes in different vertebrate species and their hybrids are studied, and the mechanisms of hybrid sterility are revealed.
